Molecular mechanisms of L-DOPA-induced dyskinesia

  title={Molecular mechanisms of L-DOPA-induced dyskinesia},
  author={P Feroz Jenner},
  journal={Nature Reviews Neuroscience},
L-DOPA (L-3,4-dihydroxyphenylalanine) remains the most effective drug for the treatment of Parkinson's disease. However, chronic use causes dyskinesia, a complex motor phenomenon that consists of two components: the execution of involuntary movements in response to drug administration, and the 'priming' phenomenon that underlies these movements' establishment and persistence. A reinterpretation of recent data suggests that priming for dyskinesia results from nigral denervation and the loss of… CONTINUE READING
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