Molecular mechanisms of IgE regulation.

@article{Bacharier2000MolecularMO,
  title={Molecular mechanisms of IgE regulation.},
  author={Leonard B. Bacharier and Raif S. Geha},
  journal={The Journal of allergy and clinical immunology},
  year={2000},
  volume={105 2 Pt 2},
  pages={
          S547-58
        }
}
  • L. Bacharier, R. Geha
  • Published 2000
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cepsilon gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype… Expand
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