Molecular mechanisms of HPV mediated neoplastic progression

  title={Molecular mechanisms of HPV mediated neoplastic progression},
  author={Rashmirani Senapati and Nihar Nalini Senapati and Bhagirathi Dwibedi},
  booktitle={Infectious Agents and Cancer},
Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squamous intraepithelial lesion to high grade squamous intraepithelial lesion are yet to be understood. Deregulation of viral gene expression and host genomic instability play a central role in virus-mediated carcinogenesis. Key events such as viral integration and epigenetic modifications… CONTINUE READING