Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation

@article{Seliger2006MolecularMO,
  title={Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation},
  author={Barbara Seliger and Ulrike Ritz and Ferrone Soldano},
  journal={International Journal of Cancer},
  year={2006},
  volume={118}
}
In humans as in other animal species, CD8+ cytotoxic T lymphocytes (CTLs) play an important if not the major role in controlling virus‐infected and malignant cell growth. The interactions between CD8+ T cells and target cells are mediated by human leukocyte antigen (HLA) class I antigens loaded with viral and tumor antigen‐derived peptides along with costimulatory receptor/ligand stimuli. Thus, to escape from CD8+ T‐cell recognition and destruction, viruses and tumor cells have developed… 
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