Molecular mechanisms of HIV integration and therapeutic intervention.

  title={Molecular mechanisms of HIV integration and therapeutic intervention.},
  author={Nick Vandegraaff and Alan N. Engelman},
  journal={Expert reviews in molecular medicine},
  volume={9 6},
Retroviruses, such as human immunodeficiency virus type 1 (HIV-1), are plus-sense RNA viruses that require reverse transcription and then DNA integration to establish a chromosomal provirus as an obligate replication intermediate. The viral enzyme reverse transcriptase synthesises linear double-stranded cDNA, which is the template for the viral enzyme integrase. Integrase catalyses two separate chemical reactions: an initial 3' processing of the nascent cDNA ends, which is followed in the cell… CONTINUE READING