Molecular mechanisms of HBV-associated hepatocarcinogenesis.

Abstract

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV-DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer-related genes. Prolonged expression of the viral… (More)
DOI: 10.1055/s-0033-1345721

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