Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.

  title={Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.},
  author={Maxim V. Frolov and Nicholas J. Dyson},
  journal={Journal of cell science},
  volume={117 Pt 11},
Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have… CONTINUE READING
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