Molecular mechanisms of DNA repair inhibition by caffeine.
@article{Selby1990MolecularMO, title={Molecular mechanisms of DNA repair inhibition by caffeine.}, author={Christopher P. Selby and Aziz Sancar}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1990}, volume={87 9}, pages={ 3522-5 } }
Caffeine potentiates the mutagenic and lethal effects of genotoxic agents. It is thought that this is due, at least in some organisms, to inhibition of DNA repair. However, direct evidence for inhibition of repair enzymes has been lacking. Using purified Escherichia coli DNA photolyase and (A)BC excinuclease, we show that the drug inhibits photoreactivation and nucleotide excision repair by two different mechanisms. Caffeine inhibits photoreactivation by interfering with the specific binding of…
119 Citations
Noncovalent drug-DNA binding interactions that inhibit and stimulate (A)BC excinuclease.
- Biology, ChemistryBiochemistry
- 1991
In the absence of significant amounts of undamaged DNA, another mechanism of inhibition was observed, in which enzyme bound to noncovalent drug-DNA complexes in the vicinity of the lesions prevents formation of preincision complexes at the lesion.
Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation
- BiologyNucleic acids research
- 2013
The results suggest that recombination pathways dependent on extensive homology search are caffeine-sensitive and stress the importance of considering direct checkpoint-independent mechanisms in the interpretation of the effects of caffeine on DNA repair.
Caffeine does not potentiate gamma-radiation induced DNA damage in ataxia telangiectasia lymphoblastoid cells.
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Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.
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- 1996
It is speculated that functional inactivation of PKA may result in increased DNA repair and the acquisition of resistance to DNA-damaging anticancer drugs in cancer.
The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine.
- Biology, ChemistryBiochemical pharmacology
- 2002
Caffeine Promotes Ultraviolet B-induced Apoptosis in Human Keratinocytes without Complete DNA Repair*
- Biology, MedicineThe Journal of Biological Chemistry
- 2011
In HaCaT keratinocytes, inhibiting the AKT/COX-2 pathways through an ATR-independent pathway is a critical molecular mechanism by which caffeine promotes UVB-induced apoptosis of unrepaired keratinocyte for elimination, indicating that AKT is an essential inhibitory target for caffeine to promote apoptosis.
Comet assay studies indicate that caffeine-mediated increase in radiation risk of embryos is due to inhibition of DNA repair.
- BiologyMutagenesis
- 1996
The data show that at the concentration necessary for increasing radiation risk (2 mM), caffeine effectively inhibits the restitution of radiation-damaged DNA.
Antineoplastic drug resistance and DNA repair.
- BiologyAnnals of oncology : official journal of the European Society for Medical Oncology
- 1991
There is an increasing need to investigate the intragenomic heterogeneity of DNA repair and correlate the repair efficiency in specific genes to aspects of drug resistance.
The Aminoglycoside Antibiotic Kanamycin Damages DNA Bases in Escherichia coli: Caffeine Potentiates the DNA-Damaging Effects of Kanamycin while Suppressing Cell Killing by Ciprofloxacin in Escherichia coli and Bacillus anthracis
- BiologyAntimicrobial Agents and Chemotherapy
- 2012
ABSTRACT The distribution of mutants in the Keio collection of Escherichia coli gene knockout mutants that display increased sensitivity to the aminoglycosides kanamycin and neomycin indicates that…
Cisplatin resistance in cyclic AMP-dependent protein kinase mutants.
- BiologyPharmacology & therapeutics
- 1998
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