Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

@inproceedings{Lynagh2012MolecularMO,
  title={Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin},
  author={Timothy Lynagh and Joseph W Lynch},
  booktitle={Front. Mol. Neurosci.},
  year={2012}
}
Ivermectin is an anthelmintic drug that works by inhibiting neuronal activity and muscular contractility in arthropods and nematodes. It works by activating glutamate-gated chloride channels (GluClRs) at nanomolar concentrations. These receptors, found exclusively in invertebrates, belong to the pentameric Cys-loop receptor family of ligand-gated ion channels (LGICs). Higher (micromolar) concentrations of ivermectin also activate or modulate vertebrate Cys-loop receptors, including the… CONTINUE READING
Highly Cited
This paper has 84 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

85 Citations

02040'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 85 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 113 references

A comparison of glycine- and ivermectin-mediated conformational changes in the glycine Frontiers in Molecular Neuroscience

Q. Wang, J. W. Lynch
2012
View 5 Excerpts
Highly Influenced

Allosteric receptors: from electric organ to cognition.

Annual review of pharmacology and toxicology • 2010
View 10 Excerpts
Highly Influenced

The gating isomerization of neuromuscular acetylcholine receptors.

The Journal of physiology • 2010
View 4 Excerpts
Highly Influenced

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 7 Excerpts
Highly Influenced

Molecular tuning of fast gating in pentameric ligand-gated ion channels.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 12 Excerpts
Highly Influenced

Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

Journal of molecular biology • 2005
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…