Molecular mechanisms of CD200 inhibition of mast cell activation.

  title={Molecular mechanisms of CD200 inhibition of mast cell activation.},
  author={Shuli Zhang and Holly M. Cherwinski and Jonathon D. Sedgwick and Joseph H. Phillips},
  journal={Journal of immunology},
  volume={173 11},
CD200 and its receptor CD200R are both type I membrane glycoproteins that contain two Ig-like domains. Engagement of CD200R by CD200 inhibits activation of myeloid cells. Unlike the majority of immune inhibitory receptors, CD200R lacks an ITIM in the cytoplasmic domain. The molecular mechanism of CD200R inhibition of myeloid cell activation is unknown. In this study, we examined the CD200R signaling pathways that control degranulation of mouse bone marrow-derived mast cells. We found that upon… CONTINUE READING

From This Paper

Topics from this paper.
68 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 68 extracted citations

Similar Papers

Loading similar papers…