Corpus ID: 6877371

Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells.

@article{Huang2006MolecularMO,
  title={Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells.},
  author={Yi-Wen Huang and Li‐Shu Wang and Hsiang-lin Chang and Weiping Ye and Michael K. Dowd and Peter Justin Wan and Young C. Lin},
  journal={Anticancer research},
  year={2006},
  volume={26 3A},
  pages={
          1925-33
        }
}
BACKGROUND Gossypol, a natural compound present in cottonseeds, displays antiproliferative and pro-apoptotic effects against various cancer cells. The (-)-gossypol enantiomer is a more potent inhibitor of cancer cell growth. Here, the molecular mechanisms of apoptosis induced by (-)-gossypol were studied in human prostate cancer cells. MATERIALS AND METHODS After the prostate cancer cell DU-145 had been treated with (-)-gossypol, the trypan blue exclusion assay and DNA fragment end-labeling… Expand
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(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells.
TLDR
Findings illustrated that (-)-gossypol reduced in vitro invasion of both the parental MAT-LyLu cells and the isolated MLL cells, suggesting that (--gOSSypol might serve as a chemotherapeutic and/or chemopreventive agent. Expand
Antitumor activity of gossypol polyphenol is mediated through apoptosis induction and sub-G1 cell cycle arrest in SEG-1 human esophageal cancer cell line.
The main objective of the present study was to evaluate the antitumor effects of gossypol in human esophageal cancer cells (SEG-1) by studying its effects on apoptosis induction and cell cycle phaseExpand
Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol.
TLDR
In the PC-3 tumour xenograft study, (-)-gossypol given once a day for 7 days significantly inhibited tumour growth in a dose-dependent manner and it suggested that cell apoptosis and inhibition of angiogenesis might contribute to the anticancer action of (--gOSSypol. Expand
Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling.
TLDR
The inhibitory effects of GP on the proliferation of MAT-LyLu prostate cancer cells are associated with modulation of TGFbeta1 and Akt signaling, which influence the expression of regulatory proteins such as cyclin D1, Cdk4 and phospho-Rb which regulate cell cycle progression of prostate cancer Cells. Expand
Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: an iTRTAQ-based quantitative proteomic analysis.
TLDR
It is found that valproic acid (VPA), a histone deacetylase inhibitor (HDACI), counteracted the suppressive effect of G OS on histone H3 acetylation and enhanced the cytotoxicity of GOS to DU145 prostate cancer cells. Expand
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TLDR
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Gossypol inhibited cell survival with decreased expression of a number of genes in the colon cancer cells, and showed significant inhibitory effect under high concentration and longtime treatment. Expand
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TLDR
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TLDR
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