Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.

@article{Ikeda2015MolecularMM,
  title={Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.},
  author={Yoshiyuki Ikeda and Akihiro Shirakabe and Christopher B. Brady and Daniela K. Zablocki and Mitsuru Ohishi and Junichi Sadoshima},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={78},
  pages={116-22}
}
Mitochondria are essential organelles that produce the cellular energy source, ATP. Dysfunctional mitochondria are involved in the pathophysiology of heart disease, which is associated with reduced levels of ATP and excessive production of reactive oxygen species. Mitochondria are dynamic organelles that change their morphology through fission and fusion in order to maintain their function. Fusion connects neighboring depolarized mitochondria and mixes their contents to maintain membrane… CONTINUE READING
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