Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity.

  title={Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity.},
  author={Eva Balada and Josep Ordi-Ros and Miquel Vilardell-Tarr{\'e}s},
  journal={Reviews in medical virology},
  volume={19 5},
Eight per cent of the human genome is derived from the integration of retroviral sequences that were incorporated in our DNA more than 25 million years ago. Although some of these elements show mutations and deletions, some HERVs are transcriptionally active and produce functional proteins. Different mechanisms have been described which link HERVs to some chronic diseases such as several cancers, nervous system diseases and autoimmune rheumatic and connective tissue diseases. They could cause… CONTINUE READING
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