Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes.

  title={Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes.},
  author={Marco Fabr{\'i}cio Dias-Peixoto and Robson Augusto Souza Santos and En{\'e}as Ricardo de Morais Gomes and M{\'a}rcia Netto Magalh{\~a}es Alves and Pedro William Machado Almeida and Leonardo Greco and Mariana Peil da Rosa and Beatrix Fauler and Michael Bader and Natalia Alenina and S{\'i}lvia Guatimosim},
  volume={52 3},
Recently there has been growing evidence suggesting that beneficial effects of angiotensin-(1-7) [Ang-(1-7)] in the heart are mediated by its receptor Mas. However, the signaling pathways involved in these effects in cardiomyocytes are unknown. Here, we investigated the involvement of the Ang-(1-7)/Mas axis in NO generation and Ca(2+) handling in adult ventricular myocytes using a combination of molecular biology, intracellular Ca(2+) imaging, and confocal microscopy. Acute Ang-(1-7) treatment… CONTINUE READING


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