Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin.

@article{Valck2010MolecularMI,
  title={Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin.},
  author={Carolina E Valck and Galia A Ram{\'i}rez and Nandy C. L{\'o}pez and Carolina Hager Ribeiro and Ismael Maldonado and Gittith S{\'a}nchez and Viviana P. Ferreira and Wilhelm Schwaeble and A dos S Ferreira},
  journal={Molecular immunology},
  year={2010},
  volume={47 7-8},
  pages={1516-21}
}
Trypanosoma cruzi (T. cruzi), the agent of Chagas' disease, the sixth most important neglected tropical disease worldwide, causes 50,000 deaths per year in Latin America. T. cruzi calreticulin (TcCRT), a highly pleiotropic chaperone molecule, plays important roles in several host/parasite interactions. Among other functions, we have previously shown that TcCRT, translocated from the endoplasmic reticulum to the area of flagellar emergence, binds human C1q and inhibits activation of the… CONTINUE READING

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Localisation of the C1q binding site within C1q receptor/calreticulin

G. R. Stuart, N. J. Lynch, +4 authors W. J. Schwaeble
FEBS Lett • 1996
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