Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems

Abstract

The aim of this work was to study the mechanism of cross-modulation between cannabinoid and opioid systems for analgesia during acute and chronic exposure. Acute coadministration of ineffectual subanalgesic doses of the synthetic cannabinoid CP-55,940 (0.2 mg/kg i.p.) and morphine (2.5 mg/kg i.p.) resulted in significant antinociception. In chronic studies… (More)
DOI: 10.1007/s00213-005-0114-4

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