Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis.

@article{Xaus2001MolecularMI,
  title={Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis.},
  author={Jordi Xaus and M{\'o}nica Comalada and Annabel F Valledor and Marina Card{\'o} and Carmen Gallego Herrero and C Soler and Jorge Lloberas and Antonio Rodr{\'i}guez Celada},
  journal={Immunobiology},
  year={2001},
  volume={204 5},
  pages={
          543-50
        }
}
Macrophages play a critical role during the immune response. Like other cells of the immune system, macrophages are produced in large amounts and most of them die through apoptosis. Macrophages survive in the presence of soluble factors, such as IFN-gamma, or extracellular matrix proteins like decorin. The mechanism toward survival requires the blocking of proliferation at the G1/S boundary of the cell cycle that is mediated by the cyclin-dependent kinase (cdk) inhibitor, p27kip and the… CONTINUE READING

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