Molecular mechanisms involved in cisplatin cytotoxicity

  title={Molecular mechanisms involved in cisplatin cytotoxicity},
  author={Peter Jordan and Maria Carmo-Fonseca},
  journal={Cellular and Molecular Life Sciences CMLS},
cis-diamminedichloroplatinum(II) or cisplatin is a DNA-damaging agent that is widely used in cancer chemotherapy. Cisplatin cross-links to DNA, forming intra- and interstrand adducts, which bend and unwind the duplex and attract high-mobility-group domain and other proteins. Presumably due to a shielding effect caused by these proteins, the cisplatin-modified DNA is poorly repaired. The resulting DNA damage triggers cell-cycle arrest and apoptosis. Although it is still debatable whether the… CONTINUE READING
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