Molecular mechanisms in successful peripheral regeneration.

Abstract

Peripheral nerve injury is normally followed by a robust regenerative response. Here we describe the early changes associated with injury from the initial rise in intracellular calcium and the subsequent activation of transcription factors and cytokines leading to an inflammatory reaction, and the expression of growth factors, cytokines, neuropeptides, and other secreted molecules involved in cell-to-cell communication promoting regeneration and neurite outgrowth. The aim of this review is to summarize the molecular mechanisms that play a part in executing successful regeneration.

0200400'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

1,541 Citations

Semantic Scholar estimates that this publication has 1,541 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Makwana2005MolecularMI, title={Molecular mechanisms in successful peripheral regeneration.}, author={Milan Makwana and Gennadij Raivich}, journal={The FEBS journal}, year={2005}, volume={272 11}, pages={2628-38} }