Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis.

@article{Rice2003MolecularMI,
  title={Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis.},
  author={David P. C. Rice and Ritva Rice and Irma Thesleff},
  journal={European journal of orthodontics},
  year={2003},
  volume={25 2},
  pages={139-48}
}
The development and growth of the skull is a co-ordinated process involving many different tissues that interact with each other to form a complex end result. When normal development is disrupted, debilitating pathological conditions, such as craniosynostosis (premature calvarial suture fusion) and cleidocranial dysplasia (delayed suture closure), can result. It is known that mutations in the fibroblast growth factor receptors 1, 2, and 3(FGFR1, 2, and 3), as well as the transcription factors… CONTINUE READING