Molecular mechanisms for nanomolar concentrations of neurosteroids at NR1/NR2B receptors.

@article{Johansson2008MolecularMF,
  title={Molecular mechanisms for nanomolar concentrations of neurosteroids at NR1/NR2B receptors.},
  author={Tobias Johansson Kristianstad University Tobias. Johansson and P A Fr{\"a}ndberg and Fred J Nyberg and Pierre Le Grev{\`e}s},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 2},
  pages={759-68}
}
Neurosteroids are endogenous steroids acting in the central nervous system. They participate in synaptic plasticity, memory and learning, Alzheimer's disease, and certain drug reward. Some mechanisms behind these effects are thought to be nongenomic, e.g., they modulate the function of the N-methyl-d-aspartate (NMDA) receptor complex. In this study, we used a Chinese hamster ovary cell line stably transfected with NMDA receptor constituents NR1/NR2B, to investigate the effects of nanomolar… CONTINUE READING

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Some mechanisms behind these effects are thought to be nongenomic , e.g. , they modulate the function of the N - methyl - d - aspartate ( NMDA ) receptor complex .
Some mechanisms behind these effects are thought to be nongenomic , e.g. , they modulate the function of the N - methyl - d - aspartate ( NMDA ) receptor complex .
Some mechanisms behind these effects are thought to be nongenomic , e.g. , they modulate the function of the N - methyl - d - aspartate ( NMDA ) receptor complex .
The coincubation of several NMDA receptor ligands in the assay indicated that PS and 3alpha5betaS act via different binding sites from those for glutamate , glycine , and dithiothreitol .
The coincubation of several NMDA receptor ligands in the assay indicated that PS and 3alpha5betaS act via different binding sites from those for glutamate , glycine , and dithiothreitol .
Some mechanisms behind these effects are thought to be nongenomic , e.g. , they modulate the function of the N - methyl - d - aspartate ( NMDA ) receptor complex .
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