Molecular mechanisms for enhanced DNA vaccine immunogenicity.

  title={Molecular mechanisms for enhanced DNA vaccine immunogenicity.},
  author={Lei Erbao Li and Nikolai Petrovsky},
  journal={Expert review of vaccines},
  volume={15 3},
In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this problem, including novel plasmid vectors and codon optimization to enhance antigen expression, new gene transfection systems or electroporation to increase delivery efficiency, protein… CONTINUE READING