Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte

@inproceedings{Cicchini2015MolecularMC,
  title={Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte},
  author={Carla Cicchini and Laura Amicone and Tonino Alonzi and Alessandra Marchetti and Carmine Mancone and Marco Tripodi},
  booktitle={Liver international : official journal of the International Association for the Study of the Liver},
  year={2015}
}
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells. Only within a correct tissue organization, in fact, they stably maintain their identity and differentiated phenotype. The loss of histotype identity, which invariably occurs in the primary hepatocytes in culture, or in vivo in particular pathological conditions (fibrosis and tumours), is mainly because of the phenomenon of epithelial-to… CONTINUE READING