Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses.

@article{Luchkina2017MolecularMC,
  title={Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses.},
  author={Natalia V. Luchkina and Sarah K. Coleman and Johanna T Huupponen and Chunlin Cai and Anna Kivist{\"o} and Tomi Taira and Kari Kein{\"a}nen and Sari E Lauri},
  journal={Neuropharmacology},
  year={2017},
  volume={112 Pt A},
  pages={46-56}
}
Synaptic recruitment of AMPA receptors (AMPARs) represents a key postsynaptic mechanism driving functional development and maturation of glutamatergic synapses. At immature hippocampal synapses, PKA-driven synaptic insertion of GluA4 is the predominant mechanism for synaptic reinforcement. However, the physiological significance and molecular determinants of this developmentally restricted form of plasticity are not known. Here we show that PKA activation leads to insertion of GluA4 to synaptic… CONTINUE READING