[Molecular mechanisms behind the immunological reaction against gluten in patients with celiac disease].

Abstract

Coeliac disease is a complex inflammatory disorder of the small intestine, induced by dietary gluten in genetically susceptible individuals. Recently, the nature of gluten-derived peptides recognized by gut-derived T cells from patients has been elucidated. It has further been established that the binding of such peptides to HLA-DQ2 and DQ8 molecules is enhanced following the modification of the peptides by the ubiquitous enzyme tissue transglutaminase. This knowledge has allowed the establishment of a molecular basis for the well-known association between coeliac disease and the expression of these HLA-molecules. This article summarizes the latest progress in coeliac disease molecular biology.

Cite this paper

@article{Nielsen2003MolecularMB, title={[Molecular mechanisms behind the immunological reaction against gluten in patients with celiac disease].}, author={Christian Nielsen and Steffen Husby and S\oren Thue Lillevang}, journal={Ugeskrift for laeger}, year={2003}, volume={165 9}, pages={917-20} }