Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

@article{Agnati2003MolecularMA,
  title={Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.},
  author={Luigi Francesco Agnati and Sergi Ferr{\'e} and Carme Llu{\'i}s and Rafael Franco and Kjell Fuxe},
  journal={Pharmacological reviews},
  year={2003},
  volume={55 3},
  pages={509-50}
}
The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers. The discovery of GABAB heterodimers started this field rapidly followed by the discovery of heteromerization among isoreceptors of several G protein-coupled receptors such as delta/kappa opioid receptors. Heteromerization was also discovered among… CONTINUE READING

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