Molecular mechanisms and function of the spindle checkpoint, a guardian of the chromosome stability.

@article{Ito2010MolecularMA,
  title={Molecular mechanisms and function of the spindle checkpoint, a guardian of the chromosome stability.},
  author={Daisuke Ito and Tomohiro Matsumoto},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={676},
  pages={
          15-26
        }
}
For equal segregation, chromosomes, which are distributed randomly in the nucleus of interphase, must be aligned at the spindle equator in mitosis before the onset of sister chromatid separation. The spindle checkpoint is a surveillance mechanism that delays the onset of sister chromatid separation while each chromosome is on the way to the spindle equator. Failure in the function of the checkpoint results in aneuploidy/polyploidy, which would be a cause of cancer. Here, we review chromosome… CONTINUE READING