Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.

@article{Kovalovsky2000MolecularMA,
  title={Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.},
  author={Dami{\'a}n Kovalovsky and Dami{\'a}n Refojo and Florian Holsboer and Eduardo Arzt},
  journal={Journal of neuroimmunology},
  year={2000},
  volume={109 1},
  pages={23-9}
}
We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1… CONTINUE READING