Molecular mechanism of voltage sensing in voltage-gated proton channels

  title={Molecular mechanism of voltage sensing in voltage-gated proton channels},
  author={Carlos Gonz{\'a}lez and Santiago Rebolledo and Marta Elena Perez and H. Peter Larsson},
  booktitle={The Journal of general physiology},
Voltage-gated proton (Hv) channels play an essential role in phagocytic cells by generating a hyperpolarizing proton current that electrically compensates for the depolarizing current generated by the NADPH oxidase during the respiratory burst, thereby ensuring a sustained production of reactive oxygen species by the NADPH oxidase in phagocytes to neutralize engulfed bacteria. Despite the importance of the voltage-dependent Hv current, it is at present unclear which residues in Hv channels are… CONTINUE READING