Molecular mechanism of vitamin D receptor action

  title={Molecular mechanism of vitamin D receptor action},
  author={Laura L Issa and Gary M. Leong and John A. Eisman},
  journal={Inflammation Research},
The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR). The VDR is a member of a superfamily of nuclear steroid hormone receptors which regulate gene transcription by interacting with response elements in gene promoters. Structure-function analysis of the VDR protein has defined… CONTINUE READING