Molecular mechanism of violacein-mediated human leukemia cell death.

@article{Ferreira2004MolecularMO,
  title={Molecular mechanism of violacein-mediated human leukemia cell death.},
  author={Carmen Ver{\'i}ssima Ferreira and Carina L. Bos and Henri H Versteeg and Giselle Zenker Justo and Nelson D’olivares Dur{\'a}n and Maikel Petrus Peppelenbosch},
  journal={Blood},
  year={2004},
  volume={104 5},
  pages={
          1459-64
        }
}
Violacein, a pigment isolated from Chromobacterium violaceum in the Amazon River, presents diverse biologic properties and attracts interest as a consequence of its antileukemic activity. Elucidation of the molecular mechanism mediating this activity will provide further relevant information for understanding its effects on the cellular physiology of untransformed cells and for considering its possible clinical application. Here, we show that violacein causes apoptosis in HL60 leukemic cells… CONTINUE READING

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