Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion

Abstract

In neurons, SNAREs, synaptotagmin and other factors catalyze Ca2+-triggered fusion of vesicles with the plasma membrane. The molecular mechanism of this process, especially the interaction between synaptotagmin and SNAREs, remains an enigma. Here we characterized this interaction by single-molecule fluorescence microscopy and crystallography. The two rigid… (More)
DOI: 10.1038/nsmb.1764

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Cite this paper

@inproceedings{Vrljic2010MolecularMO, title={Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion}, author={Marija Vrljic and Pavel Strop and James A. Ernst and R. Bryan Sutton and S. K.-K. Chu and Axel T Brunger}, booktitle={Nature Structural &Molecular Biology}, year={2010} }