Molecular mechanism of the suppression of larval skeleton by polycyclic aromatic hydrocarbons in early development of sea urchin Hemicentrotus pulcherrimus

@article{Sekiguchi2018MolecularMO,
  title={Molecular mechanism of the suppression of larval skeleton by polycyclic aromatic hydrocarbons in early development of sea urchin Hemicentrotus pulcherrimus},
  author={Toshio Sekiguchi and Koji Yachiguchi and Masato Kiyomoto and Shouzo Ogiso and Shuichi Wada and Yoshiaki Tabuchi and Chun-Sang Hong and Ajai Kumar Srivastav and Stephen D. J. Archer and Stephen B. Pointing and Kazuichi Hayakawa and Nobuo Suzuki},
  journal={Fisheries Science},
  year={2018},
  volume={84},
  pages={1073-1079}
}
Polycyclic aromatic hydrocarbons including benz[a]anthracene (BaA) are priority pollutants in the aquatic environment. Our previous study revealed that BaA and its metabolite, 4-monohydroxylated BaA (4-OHBaA) inhibit larval skeletogenesis in the sea urchin Hemicentrotus pulcherrimus. Here we report studies to elucidate the target of skeletogenesis inhibition elicited by BaA and 4-OHBaA. First, we performed an in vitro experiment using isolated micromeres which give rise to the larval… CONTINUE READING
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