Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions.

@article{Skuta1999MolecularMO,
  title={Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions.},
  author={Gabriella Skuta and Gabor M Fischer and Tam{\'a}s Jan{\'a}ky and Zolt{\'a}n Kele and P{\'a}l T. Szab{\'o} and J{\'o}zsef T{\"o}zs{\'e}r and Balazs Sumegi},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 12},
  pages={
          1915-25
        }
}
The short-term cardiac side effects of 2',3'-dideoxycytidine (ddC, zalcitabine) were studied in rats in order to understand the biochemical events contributing to the development of ddC-induced cardiomyopathy. In developing animals, ddC treatment provoked a surprisingly rapid appearance of cardiac malfunctions characterized by prolonged RR, PR, and QT intervals and J point depression. The energy metabolism in the heart was compromised, characterized by a decreased creatine phosphate/creatine… CONTINUE READING

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