Molecular mechanism of the lipid vesicle longevity in vivo.

  title={Molecular mechanism of the lipid vesicle longevity in vivo.},
  author={Gabriele Blume and Gregor Cevc},
  journal={Biochimica et biophysica acta},
  volume={1146 2},
An important, if not the chief, condition for the prolongation of the circulation times of lipid vesicles in vivo is the suppression of macromolecular adsorption onto the surface of such vesicles. This adsorption can be prevented very efficiently by a zone of suitably designed and mobile steric hindrances near the lipid layer surface. Lipid vesicles with such a surface coat, cryptosomes, thus circulate in blood for very long periods of time after systemic applications. Lipid vesicles composed… CONTINUE READING


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