Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis.

  title={Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis.},
  author={Jianzhong Liu and Shunqing Wang and Ping Zhang and Nasser Said-Al-Naief and Suzanne M. Michalek and Xu Feng},
  journal={The Journal of biological chemistry},
  volume={284 18},
Lipopolysaccharide (LPS), a common bacteria-derived product, has long been recognized as a key factor implicated in periodontal bone loss. However, the precise cellular and molecular mechanisms by which LPS induces bone loss still remains controversial. Here, we show that LPS inhibited osteoclastogenesis from freshly isolated osteoclast precursors but stimulated osteoclast formation from those pretreated with RANKL in vitro in tissue culture dishes, bone slices, and a co-culture system… CONTINUE READING

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