Molecular mechanism of the affinity interactions between protein A and human immunoglobulin G1 revealed by molecular simulations.

@article{Huang2011MolecularMO,
  title={Molecular mechanism of the affinity interactions between protein A and human immunoglobulin G1 revealed by molecular simulations.},
  author={Bo Huang and Fu-feng Liu and Xiao-yan Dong and Yan Sun},
  journal={The journal of physical chemistry. B},
  year={2011},
  volume={115 14},
  pages={4168-76}
}
Protein A (SpA) affinity chromatography has been widely used for the purification of immunoglobulin G (IgG). However, the molecular mechanism of the affinity between IgG and SpA remains unclear. In this work, molecular dynamics simulations and molecular mechanics-Poisson-Boltzmann surface area analysis were performed to investigate the molecular mechanism… CONTINUE READING