Molecular mechanism of sweetness sensation.

  title={Molecular mechanism of sweetness sensation.},
  author={Grant E Dubois},
  journal={Physiology & behavior},
  volume={164 Pt B},
The current understanding of peripheral molecular events involved in sweet taste sensation in humans is reviewed. Included are discussions of the sweetener receptor T1R2/T1R3, its agonists, antagonists, positive allosteric modulators, the transduction of its activation in taste bud cells and the coding of its signaling to the CNS. Areas of incomplete understanding include 1) signal communication with afferent nerve fibers, 2) contrasting concentration/response (C/R) functions for high-potency… CONTINUE READING
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