Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.

@article{Hong2004MolecularMO,
  title={Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.},
  author={Cheol Yi Hong and Jin Hee Park and Ryun Seop Ahn and Suhn Young Im and Hueng-Sik Choi and Jaemog Soh and S. Mellon and Keesook Lee},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 7},
  pages={2593-604}
}
Tumor necrosis factor alpha (TNF-alpha) has been demonstrated to inhibit steroidogenesis in Leydig cells at the transcriptional level of steroidogenic enzymes. However, the molecular mechanism of this observed gene repression is not well understood. We now demonstrate that nuclear factor kappaB (NF-kappaB) activated by TNF-alpha inhibits the transactivation of orphan nuclear receptors, which regulate the expression of steroidogenic-enzyme genes. TNF-alpha treatment suppressed the luteinizing… CONTINUE READING

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