Molecular mechanism of staurosporine-induced apoptosis in osteoblasts.

  title={Molecular mechanism of staurosporine-induced apoptosis in osteoblasts.},
  author={H. J. Chae and Jang Sook Kang and J O Byun and Kun Soo Han and Doo Un Kim and Sang Mi Oh and H M Kim and Soo Wan Chae and Hyung Ryong Kim},
  journal={Pharmacological research},
  volume={42 4},
Staurosporine, a microbial alkaloid, is a strong inhibitor of protein kinases. We induced apoptosis in murine osteoblast MC3T3E-1 cells by exposure to the staurosporine. Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1 (AP-1). We then prepared extracts from staurosporine-treated MC3T3E-1 cells and monitored the cleavage of acetyl-YVAD-AMC and acetyl-DEVD-AMC… CONTINUE READING

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