Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity.

@article{Yan2009MolecularMO,
  title={Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity.},
  author={Jing Yan and Yuewen Gong and Y. -M. She and Guqi Wang and Michael S. Roberts and Frank J. Burczynski},
  journal={Journal of lipid research},
  year={2009},
  volume={50 12},
  pages={2445-54}
}
Hepatocytes expressing liver fatty acid binding protein (L-FABP) are known to be more resistant to oxidative stress than those devoid of this protein. The mechanism for the observed antioxidant activity is not known. We examined the antioxidant mechanism of a recombinant rat L-FABP in the presence of a hydrophilic (AAPH) or lipophilic (AMVN) free radical generator. Recombinant L-FABP amino acid sequence and its amino acid oxidative products following oxidation were identified by MALDI… CONTINUE READING