Molecular mechanism of nitrogen mustard induced leukocyte(s) chemotaxis.


Nitrogen mustard(s) (NM) are the primary chemotherapeutic agents (Chlorambucil, BSO) that are used in treating the B-cell chronic lymphocyte leukemia (B-CLL). It is known that NM imparts oxidative stress by inducing the reactive oxygen species (ROS) and reactive nitrogen species (RNS) production in B-lymphocytes of B-CLL. It is likely that these nitrogen… (More)