Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA2, Sp1 and TBP

  title={Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA2, Sp1 and TBP},
  author={Vinayak Gupta and Abrar Ali Khan and Binu Sasi and Nitish R. Mahapatra},
  journal={Journal of Neurochemistry},
Monoamine oxidase A (MAOA) plays important roles in the pathogenesis of several neurological and cardiovascular disorders. The mechanism of transcriptional regulation of MAOA under basal and pathological conditions, however, remains incompletely understood. Here, we report systematic identification and characterization of cis elements and transcription factors that govern the expression of MAOA gene. Extensive computational analysis of MAOA promoter, followed by 5′‐promoter deletion/reporter… 

Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic l-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells

It is suggested that TET1 and DNMTs might mediate aberrant CpG methylation, associated with the misregulation of MAO-A in l-dopa administration, which might contribute to dopamine release abnormally leading to the side effects of l-Dopa.

Monoamine Oxidase A (MAO-A): A Therapeutic Target in Lung Cancer

The role of MAO-A in promoting lung cancer aggressiveness and epithelial to mesenchymal transition (EMT) is demonstrated and it is concluded that MAO -A may be considered as a potential therapeutic target for the intervention and treatment of lung carcinoma.

MiR‐29c protects against inflammation and apoptosis in Parkinson's disease model in vivo and in vitro by targeting SP1

It is presented that miR‐29c may directly target SP1 to protect against the neuroinflammatory and apoptotic responses in PD, providing a potential biomarker for PD diagnosis and treatment.

Role of Monoamine Oxidases in Heart Diseases

Transcriptional and posttranscriptional regulation of MAOs (via certain transcription factors or microRNAs) may emerge as new therapeutic strategies for treatment of cardiovascular pathological conditions.

GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid

RNA sequencing analysis revealed a number of deregulated genes involved in cell survival, migration, and function of activated DCs, and it is shown that Gata1-KODC DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21.

MicroRNA Sequencing Analysis in Obstructive Sleep Apnea and Depression: Anti-Oxidant and MAOA-Inhibiting Effects of miR-15b-5p and miR-92b-3p through Targeting PTGS1-NF-κB-SP1 Signaling

Down-regulated miR-15b-5p/miR-92b-3p in OSA patients could contribute to IHR-induced oxidative stress and MAOA hyperactivity through the eicosanoid inflammatory pathway via directly targeting PTGS1-NF-κB-SP1 signaling.



Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression*

This study reveals for the first time that KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO B and therefore may play a crucial role in modulating distinct pathophysiological steps in stress-related disorders.

Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA‐2 and NF‐κB

Both GATA‐2 and NF‐κB seem to be involved in the suppression of Epo gene expression by IL1β and TNF‐α in vitro and may be responsible for impaired Epo synthesis in inflammatory diseases in vivo.

The Role of Sp1 and AP-2 in Basal and Protein Kinase A-induced Expression of Mitochondrial Serine:Pyruvate Aminotransferase in Hepatocytes*

The results suggest that AP-2 and Sp 1 regulate basal promoter activity, and Sp1 is also involved in PKA-mediated expression of the rat SPT gene in concert with the transcriptional coactivator CBP.

Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein

The findings show that BORIS and Sp1 have opposite effects on the regulation of MAGE-A1 gene expression, and it is shown here that ectopic expression of BORis can activate transcription from its own locus, inducing all its splice variants.

Transcriptional Activation of REST by Sp1 in Huntington's Disease Models

The level of REST mRNA is increased in HD mice and in NG108 cells differentiated into neuronal-like cells and expressing a toxic mHtt fragment, and evidence that Sp1 and Sp3 bind REST promoter and interplay to fine-tune REST transcription is provided.

Regulation of monoamine oxidase A by the SRY gene on the Y chromosome

This is the first study demonstrating that the Y‐encoded transcription factor SRY is capable of regulating an X‐located gene, suggesting a novel molecular mechanism for sexual dimorphism in neural development, brain functions, and initiation/ progression of neural disorders associated with MAO A dysfunction.

Sp1 Phosphorylation and Its Regulation of Gene Transcription

Recent developments in the understanding of the role of posttranslational modifications influencing Sp1-dependent transcription are discussed, focusing mainly on phosphorylation.

GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein

It is shown that S NCA and the heme metabolism genes ALAS2, FECH, and BLVRB form a block of tightly correlated gene expression in 113 samples of human blood, where SNCA naturally abounds, and this critical link between GATA factors and SNCa may enable therapies designed to lower α-synuclein production.

Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1

  • Q. ZhuK. ChenJ. Shih
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
The core promoter region of human monoamine oxidase (MAO) A has been identified in the two 90 bp repeat sequences, which can be further divided into four imperfect tandem repeats, each containing an Sp 1 binding site in the reversed orientation, indicating that Sp1 is a controlling factor for human MAO A expression.