Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA2, Sp1 and TBP

@article{Gupta2015MolecularMO,
  title={Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia‐like conditions: key roles of the transcription factors GATA2, Sp1 and TBP},
  author={Vinayak Gupta and Abrar Ali Khan and Binu Sasi and Nitish R. Mahapatra},
  journal={Journal of Neurochemistry},
  year={2015},
  volume={134}
}
Monoamine oxidase A (MAOA) plays important roles in the pathogenesis of several neurological and cardiovascular disorders. The mechanism of transcriptional regulation of MAOA under basal and pathological conditions, however, remains incompletely understood. Here, we report systematic identification and characterization of cis elements and transcription factors that govern the expression of MAOA gene. Extensive computational analysis of MAOA promoter, followed by 5′‐promoter deletion/reporter… 

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  • Q. ZhuK. ChenJ. Shih
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
The core promoter region of human monoamine oxidase (MAO) A has been identified in the two 90 bp repeat sequences, which can be further divided into four imperfect tandem repeats, each containing an Sp 1 binding site in the reversed orientation, indicating that Sp1 is a controlling factor for human MAO A expression.
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