Molecular mechanism of mitotic Golgi disassembly and reassembly revealed by a defined reconstitution assay.

@article{Tang2008MolecularMO,
  title={Molecular mechanism of mitotic Golgi disassembly and reassembly revealed by a defined reconstitution assay.},
  author={Danming Tang and Kari Mar and Graham Warren and Yanzhuang Wang},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 10},
  pages={6085-94}
}
In mammalian cells, flat Golgi cisternae closely arrange together to form stacks. During mitosis, the stacked structure undergoes a continuous fragmentation process. The generated mitotic Golgi fragments are distributed into the daughter cells, where they are reassembled into new Golgi stacks. In this study, an in vitro assay has been developed using purified proteins and Golgi membranes to reconstitute the Golgi disassembly and reassembly processes. This technique provides a useful tool to… CONTINUE READING

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