Molecular mechanism of manganese exposure-induced dopaminergic toxicity

@article{Prabhakaran2008MolecularMO,
  title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity},
  author={K Prabhakaran and Debabrata Ghosh and Gail D. Chapman and Palur G. Gunasekar},
  journal={Brain Research Bulletin},
  year={2008},
  volume={76},
  pages={361-367}
}

Figures from this paper

Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox
TLDR
It is shown that long-term exposure to Mn during a critical period of neurodevelopment causes motor coordination dysfunction with parallel increment in oxidative stress markers, p38MAPK phosphorylation and caspase activity in the striatum and Trolox is established as a potential neuroprotective agent given its efficacy in reversing the Mn-induced neurodevelopmental effects.
α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway
TLDR
Assessment of the mechanism(s) of dopaminergic degeneration associated with α-synuclein expression in response to Mn exposure and the role of nuclear factor-κB activation as an intermediary of Mn-induced neurotoxicity indicate that the transcription factor NF-κBs, p38 MAPK, and apoptotic signaling cascades are activated by Mn in human α- synuclein-overexpressing cells.
In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function
TLDR
Investigating the developmental neurotoxicity in an in vivo model of immature rats exposed to Mn from postnatal day 8 to PN12 establishes that short-term exposure to Mn during a specific developmental window induces metabolic and neurochemical alterations in the striatum that may modulate later-life behavioral changes.
Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism
TLDR
Taurine supplementation alleviated Mn-induced locomotor deficit and mitigated oxidative stress biomarkers and preserved brain tissue mitochondrial indices of functionality, introducing taurine as a potential neuroprotective agent against Mn neurotoxicity.
Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans
TLDR
It is established that extracellular, and not intracellular, dopamine (DA) is responsible for Mn-induced DAergic neurodegeneration and that this process requires functional DA-reuptake transporter (DAT-1) and is associated with oxidative stress and lifespan reduction.
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
TLDR
It is suggested that acute manganese exposure induces cytoskeletal dysfunction prior to degeneration and that chronic manganESE exposure results in neurochemical dysfunction with overlapping features to PD.
X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity
TLDR
X-ray fluorescence imaging is introduced as a new quantitative tool for analysis of the Mn distribution in the brain with high spatial resolution and can represent a link between Mn exposure and its potential effects for development of Parkinson's disease.
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