Molecular mechanism of manganese exposure-induced dopaminergic toxicity

  title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity},
  author={K Prabhakaran and Debabrata Ghosh and Gail D. Chapman and Palur G. Gunasekar},
  journal={Brain Research Bulletin},

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Experimental evidence is provided for the hypothesis that compromised cellular defense mechanisms, i.e., glutathione (GSH), GSH-peroxidase and catalase in the brain may be involved in neuronal degeneration caused by manganese (Mn) neurotoxicity, and that the striatum is particularly susceptible to the deleterious effects of Mn.
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