Molecular mechanism of manganese exposure-induced dopaminergic toxicity
@article{Prabhakaran2008MolecularMO, title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity}, author={K Prabhakaran and Debabrata Ghosh and Gail D. Chapman and Palur G. Gunasekar}, journal={Brain Research Bulletin}, year={2008}, volume={76}, pages={361-367} }
69 Citations
BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity.
- BiologyNeurotoxicology
- 2009
Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox
- BiologyArchives of Toxicology
- 2013
It is shown that long-term exposure to Mn during a critical period of neurodevelopment causes motor coordination dysfunction with parallel increment in oxidative stress markers, p38MAPK phosphorylation and caspase activity in the striatum and Trolox is established as a potential neuroprotective agent given its efficacy in reversing the Mn-induced neurodevelopmental effects.
α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway
- BiologyToxicology mechanisms and methods
- 2011
Assessment of the mechanism(s) of dopaminergic degeneration associated with α-synuclein expression in response to Mn exposure and the role of nuclear factor-κB activation as an intermediary of Mn-induced neurotoxicity indicate that the transcription factor NF-κBs, p38 MAPK, and apoptotic signaling cascades are activated by Mn in human α- synuclein-overexpressing cells.
In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function
- BiologyPloS one
- 2012
Investigating the developmental neurotoxicity in an in vivo model of immature rats exposed to Mn from postnatal day 8 to PN12 establishes that short-term exposure to Mn during a specific developmental window induces metabolic and neurochemical alterations in the striatum that may modulate later-life behavioral changes.
α-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cells
- Biology, ChemistryBrain Research Bulletin
- 2010
Neurotoxicity mechanisms of manganese in the central nervous system.
- Biology, PsychologyAdvances in neurotoxicology
- 2021
Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism
- BiologyBiological Trace Element Research
- 2018
Taurine supplementation alleviated Mn-induced locomotor deficit and mitigated oxidative stress biomarkers and preserved brain tissue mitochondrial indices of functionality, introducing taurine as a potential neuroprotective agent against Mn neurotoxicity.
Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans
- BiologyPLoS genetics
- 2010
It is established that extracellular, and not intracellular, dopamine (DA) is responsible for Mn-induced DAergic neurodegeneration and that this process requires functional DA-reuptake transporter (DAT-1) and is associated with oxidative stress and lifespan reduction.
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
- BiologyJournal of neurochemistry
- 2009
It is suggested that acute manganese exposure induces cytoskeletal dysfunction prior to degeneration and that chronic manganESE exposure results in neurochemical dysfunction with overlapping features to PD.
X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity
- BiologyPloS one
- 2012
X-ray fluorescence imaging is introduced as a new quantitative tool for analysis of the Mn distribution in the brain with high spatial resolution and can represent a link between Mn exposure and its potential effects for development of Parkinson's disease.
References
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