Molecular mechanism of manganese exposure-induced dopaminergic toxicity

@article{Prabhakaran2008MolecularMO,
  title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity},
  author={K. Prabhakaran and D. Ghosh and G. Chapman and P. Gunasekar},
  journal={Brain Research Bulletin},
  year={2008},
  volume={76},
  pages={361-367}
}
Manganese (Mn) is an essential mineral that is found in varying amounts in aerosols or dust. Exposure to atmospheric Mn at high concentration is a risk factor in humans that can manifest as neuronal degeneration resembling Parkinson's disease (PD). Since the underlying mechanism of Mn and dopamine (DA) interaction-induced cell death remains unclear, here, we showed that Mn exposure alone to mesencephalic cells for 24h induced minimal apoptotic cell death. However, cells pre-exposed to DA for 2h… Expand
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