• DOI:10.1016/j.brainresbull.2008.03.004
Corpus ID: 206339744

Molecular mechanism of manganese exposure-induced dopaminergic toxicity

@article{Prabhakaran2008MolecularMO,
  title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity},
  author={K. Prabhakaran and D. Ghosh and G. Chapman and P. Gunasekar},
  journal={Brain Research Bulletin},
  year={2008},
  volume={76},
  pages={361-367}
}

• K. Prabhakaran, D. Ghosh, +1 author P. Gunasekar
• Published 2008
• Medicine, Biology
• Brain Research Bulletin

Manganese (Mn) is an essential mineral that is found in varying amounts in aerosols or dust. Exposure to atmospheric Mn at high concentration is a risk factor in humans that can manifest as neuronal degeneration resembling Parkinson's disease (PD). Since the underlying mechanism of Mn and dopamine (DA) interaction-induced cell death remains unclear, here, we showed that Mn exposure alone to mesencephalic cells for 24h induced minimal apoptotic cell death. However, cells pre-exposed to DA for 2h… Expand