Molecular mechanism of manganese exposure-induced dopaminergic toxicity

@article{Prabhakaran2008MolecularMO,
  title={Molecular mechanism of manganese exposure-induced dopaminergic toxicity},
  author={K. Prabhakaran and D. Ghosh and G. Chapman and P. Gunasekar},
  journal={Brain Research Bulletin},
  year={2008},
  volume={76},
  pages={361-367}
}
Manganese (Mn) is an essential mineral that is found in varying amounts in aerosols or dust. Exposure to atmospheric Mn at high concentration is a risk factor in humans that can manifest as neuronal degeneration resembling Parkinson's disease (PD). Since the underlying mechanism of Mn and dopamine (DA) interaction-induced cell death remains unclear, here, we showed that Mn exposure alone to mesencephalic cells for 24h induced minimal apoptotic cell death. However, cells pre-exposed to DA for 2h… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Manganese neurotoxicity: a focus on the neonate.
Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells.
Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.
  • J. Liccione, M. Maines
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1988
Enhancing Effect of Manganese on L‐DOPA‐Induced Apoptosis in PC12 Cells
...
1
2
3
4
5
...