Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT.

@article{Caplan2008MolecularMO,
  title={Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT.},
  author={David A Caplan and Julia O Subbotina and Sergei Yu Noskov},
  journal={Biophysical journal},
  year={2008},
  volume={95 10},
  pages={4613-21}
}
Ion-coupled transport of neurotransmitter molecules by neurotransmitter:sodium symporters (NSS) play an important role in the regulation of neuronal signaling. One of the major events in the transport cycle is ion-substrate coupling and formation of the high-affinity occluded state with bound ions and substrate. Molecular mechanisms of ion-substrate… CONTINUE READING