Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis by transcriptional regulation.

  title={Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis by transcriptional regulation.},
  author={Jeong Hae Choi and Min Jung Park and Kook Whan Kim and Yoon Ha Choi and Sun Hee Park and Won G An and Ung Suk Yang and Jaehun Cheong},
  journal={FEBS letters},
  volume={579 13},
Until now, it is known that hypoxia increases the glycolytic enzyme expression at the transcriptional level. Here, we show evidence that hypoxia increases hepatic glucose output and HIF-1 and ATF-2-mediated transactivation of phosphoenolpyruvate carboxykinase (PEPCK), which plays a critical role as a rate-limiting enzyme in gluconeogenesis, gene in liver. HIF-1 directly bound to the specific PEPCK promoter region through its cognate binding element and found as an active complex with… CONTINUE READING

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