Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis by transcriptional regulation.

@article{Choi2005MolecularMO,
  title={Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis by transcriptional regulation.},
  author={Jeong Hae Choi and Min Jung Park and Kook Whan Kim and Yoon Ha Choi and Sun Hee Park and Won G An and Ung Suk Yang and Jaehun Cheong},
  journal={FEBS letters},
  year={2005},
  volume={579 13},
  pages={2795-801}
}
Until now, it is known that hypoxia increases the glycolytic enzyme expression at the transcriptional level. Here, we show evidence that hypoxia increases hepatic glucose output and HIF-1 and ATF-2-mediated transactivation of phosphoenolpyruvate carboxykinase (PEPCK), which plays a critical role as a rate-limiting enzyme in gluconeogenesis, gene in liver. HIF-1 directly bound to the specific PEPCK promoter region through its cognate binding element and found as an active complex with… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…