Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin.

@article{Wang2006MolecularMO,
  title={Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin.},
  author={Yanmei Wang and Mu Qiao and John J. Mieyal and Lars M. Asmis and Reto H Asmis},
  journal={Free radical biology & medicine},
  year={2006},
  volume={41 5},
  pages={
          775-85
        }
}
Macrophage death is a hallmark of advanced atherosclerotic plaque, and oxidized low-density lipoprotein (OxLDL) found in these lesions is believed to contribute to macrophage injury. However, the underlying mechanisms of this phenomenon are only poorly understood. Here we show that in human monocyte-derived macrophages, OxLDL depleted intracellular glutathione (GSH) and inhibited glutathione reductase, resulting in a marked diminution of the glutathione/glutathione disulfide ratio. In the… CONTINUE READING
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Foam cell

  • L. Hegyi, J. N. Skepper, N. R. Cary, M. J. Mitchinson
  • Free Radical Biology & Medicine
  • 2006
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