Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family.

@article{Numata2008MolecularMO,
  title={Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family.},
  author={Naoki Numata and Takahide Kon and Tomohiro Shima and Kenji Imamula and Toshifumi Mogami and Reiko Ohkura and Kazuo Sutoh},
  journal={Biochemical Society transactions},
  year={2008},
  volume={36 Pt 1},
  pages={
          131-5
        }
}
Dynein is an AAA+ (ATPase associated with various cellular activities)-type motor complex that utilizes ATP hydrolysis to actively drive microtubule sliding. The dynein heavy chain (molecular mass >500 kDa) contains six tandemly linked AAA+ modules and exhibits full motor activities. Detailed molecular dissection of this motor with unique architecture was hampered by the lack of an expression system for the recombinant heavy chain, as a result of its large size. However, the recent success of… CONTINUE READING

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