Molecular mechanism of diabetic nephropathy.

  title={Molecular mechanism of diabetic nephropathy.},
  author={Reiner Lehmann and Erwin D. Schleicher},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={297 1-2},
Diabetic nephropathy is one of the main causes of renal end-stage disease. Morphologically, the development of diabetic nephropathy is characterized by progressive thickening of the glomerular basement membrane and by expansion of the mesangial matrix which correlates to glomerular filtration function. In vitro studies with cultured mesangial cells revealed that elevated glucose concentrations increase collagen synthesis similar to the in vivo situation. These studies showed that hyperglycemia… CONTINUE READING
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